Tenth seed Venus moves on to the round-of-16 where she was due to face Anastasija Sevastova, who defeated 12th seed Julia Georges 6-3, 6-3.
The two tennis superstars who have played with and against each other over the course of their long careers, showed no signs of family connection on the court as they both fought to earn points. "It's just that she is out of touch... give her a couple of tournaments and she will be back at her best".
"(Serena's) level is super high and it was very hard to close out the match, just getting one ball back", Venus said.
There was a loud roar as Serena Williams walked onto the main stadium court at the BNP Paribas Open, wearing a bulky black jacket and black tights. It's definitely not less disappointing. "Then I wouldn't be who I am", Serena said. "I have to look forward to the next match and the next time".
It was Venus' first victory over record 23-time grand slam victor Serena in their last four meetings but Serena still leads their head-to-heads 17-12.
"Missing shots that I never miss, and so close", Serena said. In the press conference after his win over Federico Delbonis, Federer has cleared that he will take rest, following his participation in Indian Wells and Miami.More news: Kane injury leaves Pochettino 'concerned'
Serena and Venus Williams were to resume their rivalry in a third-round night match, the sisters' earliest meeting since Venus won in the second round of the 1998 Australian Open. The sisters played doubles together in a Fed Cup match last month.
Venus told reporters that she never counted the 23-times grand slam champion out of the match.
"I really abhor every time we play, but I do enjoy the battle when I'm out there".
Serena praised Venus after losing last night. "I don't want to go backwards". Serena celebrated her comeback and won the first post-baby match by defeating Kazakhstan's Zarina Diyas at Indian Wells.
But she recovered from those moments to display stretches of power and precision that left you thinking that she might be back to competitive form later this year. "I'm playing a completely different player, new challenges".
What's interesting about the name Serena has chose is that the Olympic gold victor had chosen the same brand name in the past for her own clothing line, the plans for which seem deferred for now.