Expect to see a United starting lineup without Romelu Lukaku, Zlatan Ibrahimovic, Anthony Martial or Marcus Rashford on Saturday, with Ashley Young up front alone in a false nine position...
However, the summer signing from Chelsea still has a chance of continuing his unbroken run of starts in the Premier League, as the Reds look to cut Manchester City's lead back to five points before the Blues host West Ham United on Sunday.
"In France, they were very big - they had a lot of French players", he told Football Focus. It's just this game, so now it's Arsenal.
He said: "I would always try to play the best possible team, even if the Champions League match was a must-win".More news: Regal Cinemas Stock Sale Halted After Reports of Merger With Cineworld
And Pogba has sent a message to Mourinho, revealing wants to play a part in all of United's clashes in the coming month. The Gunners have been fantastic at home in this campaign as they won all seven Premier League matches at Emirates, scoring 20 and allowing only four goals in the process.
The 24-year-old played 84 minutes of the victory at Vicarage Road and notched up a goal and an assist for Jose Mourinho's men in an impressive performance.
"His ability to keep making those runs in behind is unbelievable, I played a similar position to him, and you don't realise the athleticism it takes to keep making those runs".
"And I tell my players, just think about the game". Arsenal has a high-flying offense and keeping the net intact will be a huge task for the visitors, and I am not convinced they will manage to secure a clean sheet here. It is Arsenal, and that is hard enough without us being focused on other things. Marouane Fellaini and Ander Herrera are the candidates to step in alongside Paul Pogba in middle of the park if Matic is sidelined.
"Borg's coach was telling him that all the time: "One point at a time; think about just one point".